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Susan was hit by a meteor filled with "Quantonium", which caused her to grow to 49 feet and 11 inches tall (not-quite 50 feet) on her wedding day. Exactly how much she can lift is unknown, though she is seen in the movie lifting up the top half of the hand of the massive alien robot for a long period of time - also whilst placing her foot in front of a sliding car at the edge of the broken bridge to stop it from falling in the river. She is also seen breaking the "impenetrable" force field that was holding her captive inside Gallaxhar's spaceship, even breaking through many walls in a charging force. One could think of her as invincible, due to her being resistant to most physical or energy attacks, but the movie's closest demonstration of that is her survival of direct impact from the massive meteorite, presumably due to the Quantonium.
Somewhat meek and unassertive, Susan initially wants nothing more than to return to her old life. She gradually warms to her status as a Monstress. Due to her exposure to the meteor's radiation, she is very tall and strong - which helps her in destroying Gallaxhar's weapons.
She begins the movie engaged to a weatherman named Derek Dietl. However, he rejects her after she grows tall. Susan, growing disillusioned with Derek and seeing the extent of his narcissism, later seeks revenge by humiliating him during his interview with her.
- Susan is a parody of the protagonist in Attack of the 50 Foot Woman (becoming exactly one inch shorter.)
- Susan is the 2nd female main protagonist in a DreamWorks Animation film, the first being Ginger from Chicken Run.