Susan was hit by a meteor filled with "Quantonium", which caused her to grow to 49 feet and 11 inches tall (50 feet) on her wedding day. The exact feats of how much she can lift is unknown, but is seen in the movie lifting up the top half of the hand of the massive alien robot for a long period of time also whilst placing her foot infront of a sliding car at the edge of the broken bridge to stop it from falling in the river. She is also seen breaking the impenetrable force field that was holding her captive in the Gallaxhar's Spaceship and also breaking many walls in a charging force. It could think of her as invincible because of being almost resistant to any physical or energy attack, but that is not approved in the movie except from being hit by the massive meteorite and the ball of quantonium, making her still fit to stand up.
Somewhat meek and unassertive, she initially wants nothing more than to return to her old life, but gradually warms to her status as a Monstress. Due to her exposure to the meteor's radiation, she is very tall and strong, which helps her destroy Gallaxhar 's weapons.
She was in love with a weatherman named Derek Dietl, but when she grew tall, he said it was over, causing Susan to stay away from him. After seeing him as the narcissist he is, she humiliates him during his interview with her.
- Susan is a parody of the protagonist in Attack of the 50 Foot Woman (Susan is 49-feet-11-inches tall).
- Susan is the 1st female main protaganist of the Dreamworks films the second being Tip from Home.