- “Doctor Cockroach: Forgive him, but as you can see, he has no brain
B.O.B.: Turns out, you don't need one. Totally overrated! As a matter of fact, I don't even... I forgot how to breathe! Don't know how to breathe!”
- ―B.O.B. and Doctor Cockroach to Susan Murphy[src]
B.O.B (also known as Bicarbonate Ostylezene Benzonate) was created by a genetically altered tomato with a chemically altered ranch flavored desert topping at a snack food plant. He mainly seem's to be kinda stupid and is constantly annoying the team with his stupidity. He also has a girlfriend called Jello with some pinneaple chunks, he says that her is the only thing he deserves on this world. He is voiced by Seth Rogen in the film and Eric Edelstein in the TV series. He is the tritagonist in the franchise.
- He is a reference to the film, The Blob (1958)
- He also appears in Madagascar Kartz as a playable character
- B. O. B. is voiced by Seth Rogen who did voice Mantis from Kung Fu Panda and resprised his role of him in the holiday special and sequel.